Posts tagged ‘Parkinson’s Disease’

Deep Brain Stimulation for Parkinsons’s Disease

University of Chicago Journal Club, March 2011

Editor, B Roitberg, MD


Warnke P
Hekmat-Panah J
Roitberg B

Khader-Eliyas J
Bhansali A
Dey M
Hsieh J

Article 1:

Williams A, Gill S, Varma T, Jenkinson C, Quinn N, Mitchell R, Scott R, Ives N, Rick C, Daniels J, Patel S, Wheatley K; PD SURG Collaborative Group. Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson’s disease (PD SURG trial): a randomised, open-label trial. Lancet Neurol. 2010 Jun;9(6):581-91.


The PD SURG trial we are discussing today is an open label randomized ‘intent to treat’ trial comparing medical treatment alone with combined medical and surgical treatment. The trial was conducted across 13 neurosurgical centers in the UK from 2000 to 2006. The investigators intended to prove the usefulness of deep brain stimulation in treating Parkinson’s patients by showing a 10-point difference between both groups on PDQ 39 (Parkinson’s disease Questionnaire). Secondary endpoints included changes in UPDRS (Unified Parkinsons Disease Rating Scale) and DRS II (Dementia Rating Scale II) at the end of 1 year following treatment. This article presents the follow up data at 1 year.

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Lecture 16: Parkinson’s Disease