Archive for August 2013

Russian Neurosurgical Journal; Vol 5, No 2

Journal Club No. 1, 2013

The University of Chicago Journal Club


Participating faculty: Roitberg B, Frim D, Lam S.

Residents: Monim-Mansour N; Dey M; Khader-Eliyas J; Hobbs J; Stamates M

Topic: Methylprednisolone for spinal cord injury. Is the controversy over?


Introduction: March 2013 saw the publication of new guidelines for the treatment of acute spinal cord injury, which included a clear recommendation against the use of corticosteroids, and specifically high dose methylprednisolone, for this indication. Here we review a few milestones from acceptance to rejection of methylprednisolone for acute spinal cord injury. Among the many publications on the topic we chose three. First – the NASCIS III trial, that refers to previous NASCIS studies and to me personally was a trigger to start routinely using methylprednisolone in acute spinal cord injury situations. Then we review the recommendations from the Neurosurgery March special issue – the article on “Pharmacological Therapy for Acute Spinal Cord Injury”. This guideline is unusually firm in rejecting methylprednisolone as a treatment of acute spinal cord injury. Finally, we review a large study of the use of methylprednisolone for head injury, which served as a source of data about the risks of high dose steroids. Continue reading ‘Journal Club No. 1, 2013’ »